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Trifluoperazine Hydrochloride: Full Drug Profile

Medically reviewed by Min Clinic Staff | Updated: January 2026

Trifluoperazine Hydrochloride - General Information

A phenothiazine with actions similar to chlorpromazine. It is used as an antipsychotic and an antiemetic. [PubChem]

 

Pharmacology of Trifluoperazine Hydrochloride

Trifluoperazine Hydrochloride is a trifluoro-methyl phenothiazine derivative intended for the management of schizophrenia and other psychotic disorders. Trifluoperazine Hydrochloride has not been shown effective in the management of behaviorial complications in patients with mental retardation.

 

Trifluoperazine Hydrochloride for patients

 

Trifluoperazine Hydrochloride Interactions

No information provided.

 

Trifluoperazine Hydrochloride Contraindications

A known hypersensitivity to phenothiazines, comatose or greatly depressed states due to central nervous system depressants and, in cases of existing blood dyscrasias, bone marrow depression and pre-existing liver damage.

 

Additional information about Trifluoperazine Hydrochloride

Trifluoperazine Hydrochloride Indication: For the treatment of anxiety disorders, depressive symptoms secondary to anxiety and agitation. Mechanism Of Action: Trifluoperazine Hydrochloride blocks postsynaptic mesolimbic dopaminergic D1 and D2 receptors in the brain; depresses the release of hypothalamic and hypophyseal hormones and is believed to depress the reticular activating system thus affecting basal metabolism, body temperature, wakefulness, vasomotor tone, and emesis. Drug Interactions: Not Available Food Interactions: Not Available Generic Name: Trifluoperazine Synonyms: Not Available Drug Category: Antipsychotics; Antiemetics; Phenothiazines Drug Type: Small Molecule; Approved Other Brand Names containing Trifluoperazine: Apo-Trifluoperazine; Eskazine; Eskazinyl; Fluoperazine; Jatroneural; Modalina; Novo-Trifluzine; PMS Trifluoperazine; Stelazine; Stelazine Concentrate; Stellazine; Synklor; Terfluzine; Trazine; Trifluoperazin; Trifluoperazina; Trifluoperazine Dihydrochloride; Trifluoperazine HCl; Trifluoperazine Hydrochloride; Trifluoromethylperazine; Trifluoroperazine; Trifluoroperazine Dihydrochloride; Trifluoroperazine Hydrochloride; Trifluperazine; Triflurin; Trifluroperizine; Triftazin; Triftazine; Triperazine; Triphtazin; Triphtazine; Triphthasine; Triphthazine; Triphthazine Dihydrochloride; Tryptazine; Tryptazine Dihydrochloride; Absorption: Not Available Toxicity (Overdose): Symptoms of overdose include agitation, coma, convulsions, difficulty breathing, difficulty swallowing, dry mouth, extreme sleepiness, fever, intestinal blockage, irregular heart rate, low blood pressure, and restlessness. Protein Binding: Not Available Biotransformation: Not Available Half Life: Not Available Dosage Forms of Trifluoperazine Hydrochloride: Tablet OralSyrup Oral Chemical IUPAC Name: 10-[3-(4-methylpiperazin-1-yl)propyl]-2-(trifluoromethyl)phenothiazine Chemical Formula: C21H24F3N3S Trifluoperazine on Wikipedia: https://en.wikipedia.org/wiki/Trifluoperazine Organisms Affected: Humans and other mammals